Water → 6-(2-chloropyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

HRID 16239노트

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HRID 16239 반응식
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[CH:21]=[CH:20][C:11]2[C:12]([C:16]([NH:18][CH3:19])=[O:17])=[C:13]([CH3:15])[O:14][C:10]=2[CH:9]=1.[Cl:22][C:23]1[N:28]=[C:27](Cl)[CH:26]=[CH:25][N:24]=1.O>CN(C=O)C>[Cl:22][C:23]1[N:28]=[C:27]([O:7][C:8]2[CH:21]=[CH:20][C:11]3[C:12]([C:16]([NH:18][CH3:19])=[O:17])=[C:13]([CH3:15])[O:14][C:10]=3[CH:9]=2)[CH:26]=[CH:25][N:24]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 775312,4-DichloropyrimidineHCID 167551736-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide

생성물 1

HCID 592247496-(2-chloropyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide수율 82%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
60 °C

실험 절차

Potassium carbonate (1.5 mmol) was added to a solution of 6-hydroxy-N,2-dimethylbenzofuran-3-carboxamide (1 mmol) in 5 ml DMF. After 30 mins, 2,4-dichloropyrimidine (1 mmol) was added and the reaction mixture was stirred overnight at 60° C. Water was added. The resultant solid was filtered, washed with water, and dried to give 6-(2-chloropyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide in a yield of 82%, as a solid, which was used in the next step without further purification.

후처리

  1. filtrationThe resultant solid was filtered
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-cb86a50e09fd480585599e4ca3dbb9b6
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737157B2

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