(S)-4-(1-Azido-2-(tert-butyldimethylsilyloxy)ethyl)pyridine → (S)-2-(tert-Butyldimethylsilyloxy)-1-(pyridin-4-yl)ethanamine
반응식
[N:1]([C@@H:4]([C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1)[CH2:5][O:6][Si:7]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8])=[N+]=[N-]>CO.[Pd]>[Si:7]([O:6][CH2:5][C@H:4]([C:14]1[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=1)[NH2:1])([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8]참가 물질
4
실험 절차
10% Pd/C (10 mg) was added to (S)-4-(1-azido-2-(tert-butyldimethylsilyloxy)ethyl)pyridine (58 mg, 0.208 mmol) in methanol. The reaction was degassed, and then charged with hydrogen. The reaction was stirred at room temperature overnight and filtered. The filtrate was concentrated to give the title compound (50 mg) without further purification.
후처리
- customThe reaction was degassed
- additioncharged with hydrogen
- filtrationfiltered
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-ce31dcd50948496bacd5e965ecfdedde
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08778950B2
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