1-(Trifluoromethyl)cyclobutan-1-amine hydrochloride → (1aS,5aS)-2-Pyrazin-2-yl-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (1-Trifluoromethyl-cyclobutyl)-amide

HRID 1623980

반응식

HRID 1623980 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[C:14]2[C@H:13]3[CH2:15][C@H:12]3[CH2:11][C:10]=2[C:9]([C:16]([OH:18])=O)=[N:8]1.Cl.[F:20][C:21]([F:28])([F:27])[C:22]1([NH2:26])[CH2:25][CH2:24][CH2:23]1>>[F:20][C:21]([F:28])([F:27])[C:22]1([NH:26][C:16]([C:9]2[C:10]3[CH2:11][C@@H:12]4[CH2:15][C@@H:13]4[C:14]=3[N:7]([C:2]3[CH:3]=[N:4][CH:5]=[CH:6][N:1]=3)[N:8]=2)=[O:18])[CH2:25][CH2:24][CH2:23]1

참가 물질

3

반응물 2

HCID 534157761-(Trifluoromethyl)cyclobutan-1-amine hydrochlorideHCID 68004668(4AS,5aS)-1-(pyrazin-2-yl)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid

생성물 1

HCID 51029727(1aS,5aS)-2-Pyrazin-2-yl-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (1-Trifluoromethyl-cyclobutyl)-amide

실험 절차

The title compound was prepared in a manner similar to that described in Method UU using Intermediate 4 and 1-(trifluoromethyl)cyclobutanamine hydrochloride. LCMS m/z=364.4 [M+H]+; 1H NMR (400 MHz, CDCl3) δ 0.47 (td, J=4.6, 3.2 Hz, 1H), 1.23-1.29 (m, 1H), 2.04-2.14 (m, 2H), 2.27-2.33 (m, 1H), 2.64-2.70 (m, 4H), 2.74-2.80 (m, 1H), 2.93 (d, J=16.9. Hz, 1H), 3.02 (dd, J=16.6 and 6.2 Hz, 1H), 6.99 (s, 1H), 8.42 (dd, J=2.5 and 1.5 Hz, 1H), 8.52 (d, J=2.5 Hz, 1H), 9.26 (d, J=1.4 Hz, 1H).

출처 및 근거

ORD 기록
ord-e90b3c39af794dd2bf719e1c4aef83c6
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08778950B2

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