1-(Trifluoromethyl)cyclopropanamine hydrochloride → HCID 51029816, 화합물

HRID 1623981

반응식

HRID 1623981 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[C:14]2[C@H:13]3[CH2:15][C@H:12]3[CH2:11][C:10]=2[C:9]([C:16]([OH:18])=O)=[N:8]1.Cl.[F:20][C:21]([F:27])([F:26])[C:22]1([NH2:25])[CH2:24][CH2:23]1>>[F:20][C:21]([F:27])([F:26])[C:22]1([NH:25][C:16]([C:9]2[C:10]3[CH2:11][C@@H:12]4[CH2:15][C@@H:13]4[C:14]=3[N:7]([C:2]3[CH:3]=[N:4][CH:5]=[CH:6][N:1]=3)[N:8]=2)=[O:18])[CH2:24][CH2:23]1

참가 물질

3

반응물 2

HCID 116511961-(Trifluoromethyl)cyclopropanamine hydrochlorideHCID 68004668(4AS,5aS)-1-(pyrazin-2-yl)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid

생성물 1

HCID 51029816HCID 51029816, 화합물

실험 절차

The title compound was prepared in a manner similar to that described in Method UU using Intermediate 4 and 1-(trifluoromethyl)cyclopropanamine hydrochloride. LCMS m/z=350.2 [M+H]+; 1H NMR (400 MHz, CDCl3) δ 0.47 (td, J=4.6, 3.2 Hz, 1H), 1.23-1.29 (m, 3H), 1.39-1.43 (m, 2H), 2.27-2.33 (m, 1H), 2.74-2.80 (m, 1H), 2.94 (d, J=16.8 Hz, 1H), 3.02 (dd, J=16.7 and 6.2 Hz, 1H), 7.31 (s, 1H), 8.42 (dd, J=2.5 and 1.5 Hz, 1H), 8.52 (d, J=2.5 Hz, 1H), 9.26 (d, J=1.4 Hz, 1H).

출처 및 근거

ORD 기록
ord-4db32058edd14d30ac7c19d95f29c042
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08778950B2

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