Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetaldehyde → 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetaldehyde | HCID 177 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 4-amino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide | HCID 19691899 | — |
| 촉매 | Titanium Tetrachloride | HCID 24193 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide | HCID 19691908 | — |
반응 단계
A solution of 6 g of 4-amino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide and 0.5 g of titanium tetrachloride in 100 ml of methanol is treated with 1 ml of freshly distilled acetaldehyde. 4 g of sodium cyanoborohydride are then added thereto and the mixture is stirred for 30 hours. Cold half-concentrated hydrochloric acid is added thereto, the mixture is worked up in the customary manner and 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726194 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-a7fa891adf0d455598641c30d6e12a91 |
| 출처 메모 | uspto-grants-1998_03 |