Oxalyl chloride → 8-[(2,6-Difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride

2.0 g of 8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid (6.28 mmol) were initially charged in abs. THF, 4 drops of DMF were added and 3.19 g of oxalyl chloride (25.14 mmol) were then added dropwise. The reaction mixture was stirred at RT for 3 h. Another 0.80 g of oxalyl chloride (6.29 mmol) were added, and the reaction was stirred at RT for a further 4 h. The reaction mixture was concentrated and co-evaporated with toluene three times, and the residue was dried under high vacuum. This gave 2.43 g of the title compound (103% of theory).