HCID 86717937, 화합물 → 2-Amino-4-fluoropyridin-3-ol
반응식
[F:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[OH:11]>C(O)C.[Pd]>[NH2:8][C:4]1[C:3]([OH:11])=[C:2]([F:1])[CH:7]=[CH:6][N:5]=1참가 물질
4
실험 절차
Under argon, 90 mg (0.57 mmol) of 4-fluoro-2-nitropyridin-3-ol Example 108A were dissolved in 30 ml of ethanol, and a spatula tip of palladium on activated carbon (10%) was added. The mixture was hydrogenated at RT under reduced pressure for 1.5 h. The reaction mixture was filtered off through silica gel and the filter cake was washed with plenty of ethanol. The solution was concentrated and dried. This gave 56 mg (77% of theory) of the title compound.
후처리
- filtrationThe reaction mixture was filtered off through silica gel
- washthe filter cake was washed with plenty of ethanol
- concentrationThe solution was concentrated
- customdried
출처 및 근거
- ORD 기록
- ord-ab89a6b7b2954783916f3e6ee4525f5f
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08778964B2
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