Ammonia → 2-(Methylthio)pyrimidin-4-amine
반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[NH3:10]>CO>[CH3:9][S:8][C:4]1[N:3]=[C:2]([NH2:10])[CH:7]=[CH:6][N:5]=1참가 물질
4
실험 절차
A mixture of 4-chloro-2-methylsulfanylpyrimidine (8 g) and 7N ammonia in methanol (100 mL) at 100° C. was stirred for 2 days in a sealed tube, cooled, concentrated, treated with water, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The concentrate was triturated with ethyl ether and filtered. 1H NMR (300 MHz, CDCl3) δ 8.06 (d, 1H), 6.12 (d, 1H), 4.83 (s, 2H), 2.51 (s, 3H).
후처리
- temperaturecooled
- concentrationconcentrated
- additiontreated with water
- extractionextracted with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated
- customThe concentrate was triturated with ethyl ether
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-ee4c67b25ee64efdb3c0893c80b0defa
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07737159B2
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