Ammonia → 2-(Methylthio)pyrimidin-4-amine

HRID 16247

반응식

HRID 16247 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[NH3:10]>CO>[CH3:9][S:8][C:4]1[N:3]=[C:2]([NH2:10])[CH:7]=[CH:6][N:5]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 971134-Chloro-2-methylthiopyrimidine

생성물 1

HCID 2592252-(Methylthio)pyrimidin-4-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-chloro-2-methylsulfanylpyrimidine (8 g) and 7N ammonia in methanol (100 mL) at 100° C. was stirred for 2 days in a sealed tube, cooled, concentrated, treated with water, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The concentrate was triturated with ethyl ether and filtered. 1H NMR (300 MHz, CDCl3) δ 8.06 (d, 1H), 6.12 (d, 1H), 4.83 (s, 2H), 2.51 (s, 3H).

후처리

  1. temperaturecooled
  2. concentrationconcentrated
  3. additiontreated with water
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated
  8. customThe concentrate was triturated with ethyl ether
  9. filtrationfiltered

출처 및 근거

ORD 기록
ord-ee4c67b25ee64efdb3c0893c80b0defa
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737159B2

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