Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → 4-{6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol | HCID 2734624 | — |
| 반응물 | 2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine | HCID 11609049 | — |
| 생성물 | 4-{6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}phenol | HCID 135453073 | 59.7% |
반응 단계
Using Method B with 275 mg (0.93 mmol) 2a and 242 mg (1.10 mmol) 4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)phenol, 83 mg pure title compound (59.7%) were obtained after purification by preparative HPLC (eluent:AcOEt). Reaction time: 48 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737152B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-4a87b0a24faa4978b9e913d43971f731 |
| 출처 메모 | uspto-grants-2010_06 |