1H-Pyrazol-3-amine, 5-methyl- → N-(5-methyl-1H-pyrazol-3-yl)acetamide

반응식

[NH:1]1[CH:5]=[CH:4][C:3]([NH:6][C:7](=[O:9])[CH3:8])=[N:2]1.[CH3:10]C1NN=C(N)C=1>>[CH3:10][C:5]1[NH:1][N:2]=[C:3]([NH:6][C:7](=[O:9])[CH3:8])[CH:4]=1

참가 물질

반응물 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-

HCID 178474341HCID 178474341, 화합물

생성물 1

HCID 5246311N-(5-methyl-1H-pyrazol-3-yl)acetamide수율 70.4%

실험 절차

Title compound was prepared by a method analogous to that described for Intermediate 1, replacing 1H-pyrazol-3-amine with 5-methyl-1H-pyrazol-3-amine, (ALDRICH, 1.01 g, 7.25 mmol, 70.4% yield). 1H NMR (300 MHz, DMSO-d6) δ ppm: 11.89 (s, 1H), 10.16 (s, 1H), 6.22 (s, 1H), 2.16 (s, 3H), 1.94 (s, 3H). [ES+MS] m/z 140 (MH+).

출처 및 근거

ORD 기록: ord-02ea37c47ad54703ac36850fe2490f62
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08779153B2

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