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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1625133생성일: 2026년 10월 27일

Trifluoroacetic acid → 2-[2-hydroxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one

https://huagongshe.com/reaction/1625133

반응식

참여 물질

역할이름HCID투입량
반응물Trifluoroacetic acidHCID 6422—
반응물2-[2-tert-butoxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-oneHCID 178450505—
용매DichloromethaneHCID 6344—
생성물2-[2-hydroxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-oneHCID 178515043—

반응 단계

Compound 92 was prepared by adding trifluoroacetic acid to a solution of 2-[2-tert-butoxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one in dichloromethane. The reaction was stirred at ambient temperature for 18 hours, then concentrated in vacuo. Purification by LC provided the product as a white solid. MS (ES): m/z 400 (M H), 382, 200, 136. Compound 92 is shown below.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08779131B2
출처 데이터셋uspto-grants-2014_07
ORD IDord-a5b62c916f354d34adf9b20cbef2f4fc
출처 메모uspto-grants-2014_07