Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylboronic Acid → 2-(3,4,5-Trimethoxyphenylamino)-6-phenylpyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylboronic Acid | HCID 66827 | — |
| 반응물 | 2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine | HCID 11609049 | — |
| 생성물 | 2-(3,4,5-Trimethoxyphenylamino)-6-phenylpyrazine | HCID 11580863 | 36.2% |
반응 단계
Using Method C with 200 mg (0.68 mmol) 2a and 100 mg (0.82 mmol) phenylboronic acid, 83 mg (22.9%) pure title compound were obtained after preparative HPLC (eluent: AcOEt) purification of the whole batch. Reaction time: 20 hours. 1H-NMR (DMSO), δ (ppm), J (Hz): 3.64 (s, 3H, CH3O(4′)), 3.83 (s, 6H, CH3O(3′+5′)), 7.26 (s, 2H, Harom(2+6)), 7.51 (m, 3H, Harom 3′+4′+5′), 8.14 (m, 2H, Harom2′+6′), 8.16 (s, 1H, HP5), 8.52 (s, 1H, HP3), 9.58 (s, 1H, NHamine); MS, (C19H19N3O3), m/z: 338 [M++1, 100].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737152B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-a766dcecfe7e4418a543639f2fa6f672 |
| 출처 메모 | uspto-grants-2010_06 |