4-Formylphenylboronic Acid → 4-{6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}benzaldehyde

참여 물질

역할	이름	HCID	투입량
반응물	4-Formylphenylboronic Acid	HCID 591073	—
반응물	2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine	HCID 11609049	—
생성물	4-{6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}benzaldehyde	HCID 11710340	61.7%

반응 단계

Using Method C with 200 mg (0.68 mmol) 2a and 123 mg (0.82 mmol) 4-formylphenylboronic acid, 153 mg (61.7%) pure title compound were obtained after preparative HPLC (eluent: AcOEt) purification of the whole batch. Reaction time: 24 hours. 1H-NMR (DMSO), δ (ppm), J (Hz): 3.64 (s, 3H, CH3O(4′)), 3.83 (s, 6H, CH3O(3′+5′)), 7.25 (s, 2H, Harom(2+6)), 8.05 (d, 2H, Harom 2′+6′, J=8.22), 8.23 (s, 1H, HP5), 8.35 (d, 2H, Harom3′+5′), 8.64 (s, 1H, HP3), 9.68 (s, 1H, NHamine), 10.08 (s, 1H, CHO); MS, (C20H19N3O4), m/z: 395 [M++1, 100].

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07737152B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-af231bab58f548f49891160e4d56d157
출처 메모	uspto-grants-2010_06