Dichloromethane → 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

HRID 1625486노트

반응식

HRID 1625486 반응식
[Cl:1]CCl.[F:4][C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][C:21]=1[F:22])[CH2:8][N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15](O)=[O:16])[C:10]1=[O:18].C(Cl)(C(Cl)=O)=O>CN(C=O)C>[F:4][C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][C:21]=1[F:22])[CH2:8][N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([Cl:1])=[O:16])[C:10]1=[O:18]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 534279691-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

생성물 1

HCID 593623351-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The flask was charged with dichloromethane, 20 mg of 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid, DMF, (COCl)2 was added slowly via syringe. Then the resulted mixture was allowed to stir at room temperature for 3 h. After TLC show the reaction was complete, the solvent was removed under high vacuum to give 25 mg of crude product, which was used for the next step reaction without further purification.

후처리

  1. additionwas added slowly via syringe
  2. customthe solvent was removed under high vacuum

출처 및 근거

ORD 기록
ord-f43a7b016f0d4e24bf5199748fb79bbc
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08778977B2

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