Bromine → 2-Bromo-1-(4'-bromo-1,1'-biphenyl-4-yl)ethanone

HRID 1625490

반응식

HRID 1625490 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:16])[CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[Br:17]Br>C(Cl)Cl>[Br:17][CH2:15][C:14]([C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=2)=[CH:9][CH:10]=1)=[O:16]

참가 물질

4

반응물 2

HCID 24408BromineHCID 798061-(4'-Bromo(1,1'-biphenyl)-4-yl)ethan-1-one

생성물 1

HCID 32747482-Bromo-1-(4'-bromo-1,1'-biphenyl-4-yl)ethanone수율 88.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 1-[4-(4-bromophenyl)phenyl]ethanone (5 g, 18.17 mmol) in CH2Cl2 (40 mL) is added bromine (983 μL, 19 mmol). The resulting mixture is stirred for 48 hours at room temperature. The mixture is diluted with dichloromethane, washed with saturated aqueous sodium bicarbonate, water, brine, dried over anhydrous sodium sulfate and concentrated. The crude solid is triturated with ether to give 2-bromo-1-[4-(4-bromophenyl)phenyl]ethanone (5.7 g, 88.6%) as a white solid.

후처리

  1. washwashed with saturated aqueous sodium bicarbonate, water, brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated
  4. customThe crude solid is triturated with ether

출처 및 근거

ORD 기록
ord-56e3e94580c14036b2fa6cd417fff457
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08779156B2

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