p-Bromobenzenesulfonyl chloride → 4-Bromo-benzenesulfonic acid (S)-2-(methyl-prop-2-ynyl-amino)-3-phenyl-propyl ester

반응식

[CH3:1][N:2]([CH2:13][C:14]#[CH:15])[C@@H:3]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:4][OH:5].[Br:16][C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[CH3:1][N:2]([CH2:13][C:14]#[CH:15])[C@@H:3]([CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[CH2:4][O:5][S:23]([C:20]1[CH:21]=[CH:22][C:17]([Br:16])=[CH:18][CH:19]=1)(=[O:25])=[O:24]

참가 물질

반응물 2

HCID 7396p-Bromobenzenesulfonyl chloride

HCID 57789236(2S)-2-[methyl(prop-2-yn-1-yl)amino]-3-phenylpropan-1-ol

생성물 1

HCID 866329454-Bromo-benzenesulfonic acid (S)-2-(methyl-prop-2-ynyl-amino)-3-phenyl-propyl ester수율 47%

실험 절차

Compound 4c is synthesized by general procedure K from 4b p-bromo-benzene sulfonyl chloride in 47% yield (1.58 g, 1.41 mmol).

출처 및 근거

ORD 기록: ord-77bfbb9f0c274f1ba0209de67f00b9a2
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08784775B2

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