HCID 86632947, 화합물 → Desmethylselegiline

HRID 1625545노트

반응식

HRID 1625545 반응식
Cl.[CH3:2][C@@H:3]([NH2+:11][CH2:12][C:13]#[CH:14])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>ClCCl.C(=O)([O-])[O-].[Na+].[Na+]>[CH3:2][C@@H:3]([NH:11][CH2:12][C:13]#[CH:14])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 1

HCID 86632947HCID 86632947, 화합물

생성물 1

HCID 185859Desmethylselegiline

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 10340Sodium Carbonate용매

실험 절차

840 mg (4 mmol) ((R)-1-methyl-2-phenyl-ethyl)-prop-2-ynyl-ammonium hydrochloride (Sigma) is dissolved in 10 ml dichloromethane and 1M aqueous sodium carbonate. The organic phase is separated. The aqueous phase is extracted three times with 10 ml dichloromathane. The combined organic phases are washed with brine and dried with magnesium sulfate. The crude product 6a is used without further purification.

후처리

  1. customThe organic phase is separated
  2. extractionThe aqueous phase is extracted three times with 10 ml dichloromathane
  3. washThe combined organic phases are washed with brine
  4. dry with materialdried with magnesium sulfate
  5. customThe crude product 6a is used without further purification

출처 및 근거

ORD 기록
ord-4564f419b9bf41adb375b33df70200a3
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08784775B2

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