Methanesulfonate → Neramexane Mesylate

반응식

[NH2:1][C:2]1([CH3:12])[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4]([CH3:11])([CH3:10])[CH2:3]1.[S:13]([O-:17])(=[O:16])(=[O:15])[CH3:14]>>[S:13]([OH:17])(=[O:16])(=[O:15])[CH3:14].[NH2:1][C:2]1([CH3:12])[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4]([CH3:11])([CH3:10])[CH2:3]1

참가 물질

반응물 2

HCID 85257Methanesulfonate

HCID 6433106Neramexane

생성물 1

HCID 11425584Neramexane Mesylate

실험 절차

In one embodiment, crude 1-amino-1,3,3,5,5-pentamethylcyclohexane comprising 1-amino-1,3,3-trans-5-tetramethylcyclohexane is subjected to mesylate formation according to the process of the invention, wherein 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate is formed comprising 1-amino-1,3,3-trans-5-tetramethylcyclohexane mesylate.

출처 및 근거

ORD 기록: ord-735117ee4ae248a6b6c3f6ea931c023e
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08784847B2

반응 노트

불러오는 중…