Ethyl trifluoroacetate → 2,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one

HRID 1625650노트

반응식

HRID 1625650 반응식
[NH:1]1[CH2:7][CH2:6][CH2:5][C@H:2]1[CH2:3][OH:4].[F:8][C:9]([F:16])([F:15])[C:10](OCC)=[O:11]>C1COCC1>[F:8][C:9]([F:16])([F:15])[C:10]([N:1]1[CH2:7][CH2:6][CH2:5][C@H:2]1[CH2:3][OH:4])=[O:11]

참가 물질

4

반응물 2

HCID 9794Ethyl trifluoroacetateHCID 640091L-Prolinol2회

생성물 1

HCID 186601442,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one수율 97%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매4회

실험 절차

L-prolinol (2.0 g, 20 mmol) was dissolved in 20 ml of THF. On the other hand, ethyl trifluoroacetate (3.0 g, 21 mmol) was dissolved in 20 ml of THF. Then, the latter THF solution was instilled in the former THF solution containing the L-prolinol, and this was stirred for 12 hours. This reaction solution was vacuum concentrated. Thus, Compound 1 was obtained (3.7 g, yield: 97%). The result of NMR analysis with respect to this compound is shown below.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d04ba149aaa04863af22ab17ba372ac8
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785121B2

반응 노트

불러오는 중…