Oxalyl chloride → 4-Ethylphenylacetyl chloride

HRID 1625853

반응식

HRID 1625853 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1)[CH3:2].C(Cl)(=O)C([Cl:16])=O>ClCCl.CN(C)C=O>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([Cl:16])=[O:12])=[CH:5][CH:4]=1)[CH3:2]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 84403(4-Ethylphenyl)acetic acid

생성물 1

HCID 155783544-Ethylphenylacetyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

4-Ethylphenylacetic acid (3.0 g) (see Japanese Unexamined Patent Publication 63-233975) was dissolved in dichloromethane (15 ml), and thereto were added oxalyl chloride (6.0 ml) and N,N-dimethylformamide (one drop). The mixture was stirred at room temperature for 1.5 hours. The reaction mixture was evaporated under reduced pressure, and the residue was subjected to azeotropic distillation with toluene to give a crude 4-ethylphenylacetyl chloride, which was used in the subsequent step without further purification.

후처리

  1. customThe reaction mixture was evaporated under reduced pressure
  2. distillationthe residue was subjected to azeotropic distillation with toluene

출처 및 근거

ORD 기록
ord-31eeafb1227e43058a73a4f990730905
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785403B2

연결된 노트

불러오는 중…