Water → 5-Bromo-3-chloro-4-methyl-1H-pyrrolo[2,3-b]pyridine

HRID 1626007노트

반응식

HRID 1626007 반응식
[Br:1][C:2]1[C:3]([CH3:11])=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[Cl:12]N1C(=O)CCC1=O.O>O1CCCC1>[Br:1][C:2]1[C:3]([CH3:11])=[C:4]2[C:10]([Cl:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 401522575-bromo-4-methyl-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 534129335-Bromo-3-chloro-4-methyl-1H-pyrrolo[2,3-b]pyridine수율 96.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The compound obtained in Step 3 of Example 36 (323 mg) was dissolved in tetrahydrofuran (6 ml). N-Chlorosuccinimide (225 mg) was added and the mixture was stirred at room temperature for three days. Water was added to the reaction solution, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated to give the title compound (364 mg).

후처리

  1. extractionfollowed by extraction with chloroform
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-18089958fb4b4357bee6616174b7a234
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785438B2

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