Potassium Carbonate → 2-(4-(4-(2,3-Dimethylphenyl)piperazin-1-yl)-3-hydroxybutyl)isoindoline-1,3-dione

HRID 1626308

반응식

HRID 1626308 반응식
[O:1]1[CH2:3][CH:2]1[CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16].C(=O)([O-])[O-].[K+].[K+].Cl.[CH3:24][C:25]1[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][C:26]=1[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>CN(C)C=O>[CH3:24][C:25]1[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][C:26]=1[N:32]1[CH2:33][CH2:34][N:35]([CH2:3][CH:2]([OH:1])[CH2:4][CH2:5][N:6]2[C:14](=[O:15])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]2=[O:16])[CH2:36][CH2:37]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 3394332-[2-(oxiran-2-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dioneHCID 130346471-(2,3-Dimethylphenyl)piperazine hydrochloride

생성물 1

HCID 672050722-(4-(4-(2,3-Dimethylphenyl)piperazin-1-yl)-3-hydroxybutyl)isoindoline-1,3-dione수율 46.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
110 °C

실험 절차

To a mixture of 2-(2-(oxiran-2-yl)ethyl)isoindoline-1,3-dione obtained in step 2 (0.30 g, 1.38 mmol) and potassium carbonate (0.48 g, 3.45 mmol) in N,N-dimethylformamide (3.0 ml), was added 1-(2,3-dimethylphenyl)piperazine hydrochloride (0.31 g, 1.38 mmol) at room temperature. The resulting reaction mixture was stirred at 110° C. for 18 hours. After the reaction complete, the reaction mixture thus obtained was filtered through a plug of Celite. The filtrate was concentrated under reduced pressure to obtain the title compound (0.26 g). The compound was used for the next step without further purification.

후처리

  1. customThe resulting reaction mixture
  2. customAfter the reaction complete, the reaction mixture thus obtained
  3. filtrationwas filtered through a plug of Celite
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-efd2fed5268e435e9d7457c3c1ed6d7f
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785453B2

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