Hydrochloride methanol → 1260081-87-5

HRID 1626329노트

반응식

HRID 1626329 반응식
CO.Cl.[N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[S:14]([NH:17][C:18]2[CH:38]=[CH:37][C:21]([C:22]([N:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]3)=[O:23])=[CH:20][CH:19]=2)(=[O:16])=[O:15])[CH:7]=[CH:6][CH:5]=1>>[N:24]1([C:22]([C:21]2[CH:20]=[CH:19][C:18]([NH:17][S:14]([C:12]3[CH:11]=[CH:10][CH:9]=[C:8]4[C:13]=3[N:4]=[CH:5][CH:6]=[CH:7]4)(=[O:16])=[O:15])=[CH:38][CH:37]=2)=[O:23])[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1

참가 물질

3

반응물 2

HCID 21893726Hydrochloride methanolHCID 59634969HCID 59634969, 화합물

생성물 1

HCID 596349121260081-87-5수율 94.3%

실험 절차

To a solution of MeOH.HCl, Boc protected amine 138 (2 gm, 4.03 mmol) was added and the resulting mixture was stirred for 1 hr. After completion of reaction, solvent was removed under reduced pressure, washed with water followed by addition of NaHCO3 and extracted with DCM. The organic layer was dried over Na2SO4 and evaporated under reduced pressure to afford product 139 (1.5 gm, 94.30% yield).

후처리

  1. additionwas added
  2. customAfter completion of reaction, solvent
  3. customwas removed under reduced pressure
  4. washwashed with water
  5. additionfollowed by addition of NaHCO3
  6. extractionextracted with DCM
  7. dry with materialThe organic layer was dried over Na2SO4
  8. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-0363432c785a43418848cd69490da63a
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785450B2

반응 노트

불러오는 중…