Trifluoroacetic acid → 2-(3,5-Dichloro-pyridin-2-YL)-ethylamine

HRID 1626476노트

반응식

HRID 1626476 반응식
[Cl:1][C:2]1[C:3]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[C:3]([CH2:9][CH2:10][NH2:11])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67287275HCID 67287275, 화합물

생성물 1

HCID 230682892-(3,5-Dichloro-pyridin-2-YL)-ethylamine수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Tert-butyl 2-(3,5-dichloropyridin-2-yl)ethylcarbamate (50 mg, 0.17 mmol) was diluted with DCM (500 uL) followed by the addition of TFA (500 μl). After stirring for 2 hours, the reaction was concentrated and placed under vacuum to yield the desired compound (32 mg, 0.17 mmol, 98% yield).

후처리

  1. concentrationthe reaction was concentrated

출처 및 근거

ORD 기록
ord-c27ff43ad9ef4678b90d8450ff1c384c
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785445B2

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