Dimethylamine → 2-(Dimethylamino)-6-(trifluoromethyl)pyridine-3-carbaldehyde

HRID 1626480노트

반응식

HRID 1626480 반응식
Cl[C:2]1[N:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:14][NH:15][CH3:16]>C1COCC1>[CH3:14][N:15]([CH3:16])[C:2]1[N:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 467399062-Chloro-6-(trifluoromethyl)pyridine-3-carbaldehyde

생성물 1

HCID 582590702-(Dimethylamino)-6-(trifluoromethyl)pyridine-3-carbaldehyde수율 41.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

To a stirred solution of 2-chloro-6-(trifluoromethyl)nicotinaldehyde (115 mg, 0.549 mmol) in THF (1 mL) was added dimethylamine (823 μl, 1.65 mmol). The reaction was heated to 50° C. and stirred for 3 hours. The reaction was loaded onto silica gel and eluted with 5% ethyl acetate/hexanes to 50% ethyl acetate/hexanes to yield the desired compound (50 mg, 0.229 mmol, 41.8% yield).

후처리

  1. washeluted with 5% ethyl acetate/hexanes to 50% ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-e5492b26e36846f8a75d4a64a613d23f
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785445B2

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