Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Acetamidobutyric acid → (S)-N-(4-(2-(4-(3-cyclopropylureido)phenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-4-oxobutyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Acetamidobutyric acid | HCID 18189 | — |
| 반응물 | (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea | HCID 46894114 | — |
| 생성물 | (S)-N-(4-(2-(4-(3-cyclopropylureido)phenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-4-oxobutyl)acetamide | HCID 66679045 | 39% |
반응 단계
Method as example 127 using 4-acetamidobutanoic acid and (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 3) as starting materials. Purified by Prep HPLC at low pH to afford a white solid (46.5 mg, 0.089 mmol, 39%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08785457B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-fc5442640481436f99ea0d671f68ad48 |
| 출처 메모 | uspto-grants-2014_07 |