4-Aminopyridine → N2-(pyridin-4-yl)-N6-(3,4,5-trimethoxyphenyl)pyrazine-2,6-diamine

HRID 16268

반응식

HRID 16268 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:13][C:14]2[CH:19]=[N:18][CH:17]=[C:16](Cl)[N:15]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[NH2:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1>>[N:25]1[CH:26]=[CH:27][C:22]([NH:21][C:16]2[CH:17]=[N:18][CH:19]=[C:14]([NH:13][C:5]3[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=3)[N:15]=2)=[CH:23][CH:24]=1

참가 물질

3

반응물 2

HCID 17274-AminopyridineHCID 116090492-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine

생성물 1

HCID 24879390N2-(pyridin-4-yl)-N6-(3,4,5-trimethoxyphenyl)pyrazine-2,6-diamine수율 10%

실험 절차

Using Method R, with 200 mg of 2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine (all amounts scaled accordingly) and 4-aminopyridine, 25 mg of title compound were obtained. Yield: 10%. 1H NMR (250 MHz, DMSO-d6) δ 3.64 (s, 3 H), 3.68 (s, 6 H), 6.83 (s, 2 H), 7.55 (d, 2 H, J=6.3 Hz), 7.62 (s, 1 H), 7.69 (s, 1 H), 8.25 (d, 2 H, J=6.3 Hz), 9.23 (s, 1 H), 9.66 (s, 1 H). 13C NMR (62.5 MHz, DMSO-d6) δ 55.66, 60.14, 97.52, 112.07, 122.57, 123.96, 132.67, 136.40, 147.39, 148.88, 149.83, 150.18, 152.93. m/z 354.2 [(M+H)+ calcd for C18H19N5O3 353.2].

출처 및 근거

ORD 기록
ord-982385f4741940858fe347c46dd6ac9b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737152B2

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