Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → (1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,7,10a-decahydrophenanthrene-1-carbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Phosphorus trichloride | HCID 24387 | — |
| 반응물 | Dihydroabietic acid | HCID 227277 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,7,10a-decahydrophenanthrene-1-carbonyl chloride | HCID 88415966 | 93.3% |
반응 단계
A mixture of dihydroabietic acid (1.0 eq. 9.95 mmol), phosphorous (III) chloride (1.1 eq. 10.95 mmol) and DMF (0.1 ml) is refluxed overnight in THF (20 ml). The reaction mass is filtered under suction and concentrated under vacuum to give 2.98 g (93%) yellow oil. The compound is used immediately for the next step without any purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08785502B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-56121c6b026d4937a41bbe65d50eda61 |
| 출처 메모 | uspto-grants-2014_07 |