2-Naphthol → 2-(3,4,5-Trimethoxyphenylamino)-6-(naphthalen-2-yloxy)pyrazine

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:13][C:14]2[CH:19]=[N:18][CH:17]=[C:16](Cl)[N:15]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][C:22]=1[OH:31]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:13][C:14]2[CH:19]=[N:18][CH:17]=[C:16]([O:31][C:22]3[CH:23]=[CH:24][C:25]4[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:21]=3)[N:15]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

참가 물질

반응물 2

HCID 86632-Naphthol

HCID 116090492-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine

생성물 1

HCID 248793292-(3,4,5-Trimethoxyphenylamino)-6-(naphthalen-2-yloxy)pyrazine수율 38%

실험 절차

Using Method X, with 200 mg of 2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine (all amounts scaled accordingly) and 2-naphthol, 78 mg of the title compound were obtained.

출처 및 근거

ORD 기록: ord-0eafb53a66c34eaab39cb84046766e22
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07737152B2

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