Hydrogen chloride-ethyl acetate → 1-[[[4-(4-Propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester hydrochloride

HRID 1627456노트

반응식

HRID 1627456 반응식
[ClH:1].C(OCC)(=O)C.[CH3:8][O:9][C:10]([C:12]1([NH:18][C:19]([C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][CH3:35])[CH2:29][CH2:28]3)=[CH:23][CH:22]=2)=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11]>C(OCC)(=O)C>[ClH:1].[CH3:8][O:9][C:10]([C:12]1([NH:18][C:19]([C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][CH3:35])[CH2:29][CH2:28]3)=[CH:23][CH:22]=2)=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11]

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 576728301-[[[4-(4-Propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester

생성물 1

HCID 671820191-[[[4-(4-Propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester hydrochloride수율 66%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

1 ml of 4N hydrochloric acid/ethyl acetate solution was added to a solution of 120 mg (0.31 mmol) of 1-[[[4-(4-propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester in 10 ml of ethyl acetate, and the mixture was stirred at room temperature for 30 minutes. The precipitated crystal was collected by filtration to obtain 87 mg (66%) of the title compound.

후처리

  1. filtrationThe precipitated crystal was collected by filtration

출처 및 근거

ORD 기록
ord-ab12e1af82f34f1aaca94aed4f4e5f11
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785631B2

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