Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 1-aminocyclohexanoate → 1-[[[4-[2-[4-(4-Morpholinyl)-1-piperazinyl]-4-thiazolyl]phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 1-aminocyclohexanoate | HCID 4048819 | — |
| 반응물 | 4-[2-[4-(4-Morpholinyl)-1-piperazinyl]-4-thiazolyl]benzoic acid hydrobromide | HCID 67181771 | — |
| 생성물 | 1-[[[4-[2-[4-(4-Morpholinyl)-1-piperazinyl]-4-thiazolyl]phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester | HCID 67182490 | — |
반응 단계
4.50 g (9.90 mmol) of 4-[2-[4-(4-morpholinyl)-1-piperazinyl]-4-thiazolyl]benzoic acid hydrobromide was used instead of 4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzoic acid hydrobromide and 1.57 g (9.90 mmol) of 1-aminocyclohexanecarboxylic acid methyl ester was used instead of 1-aminocyclohexanecarboxylic acid phenylmethyl ester in the process according to Reference Example 160 to obtain 5.08 g (quantitative) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08785631B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-d185dddbb10247adb133a539bf607264 |
| 출처 메모 | uspto-grants-2014_07 |