Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 2-Chloro-6-(3-fluorophenoxy)pyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 3-Fluorophenol | HCID 9743 | — |
| 반응물 | 2,6-Dichloropyrazine | HCID 78504 | — |
| 용매 | Cyclohexane | HCID 8078 | — |
| 생성물 | 2-Chloro-6-(3-fluorophenoxy)pyrazine | HCID 53486074 | 92% |
반응 단계
Using Method DD with 2,6-dichloropyrazine (250 mg, 1.69 mmol) and 3-fluorophenol (166 μL, 1.86 mmol, d=1.25 g/mL), and purification by column chromatography (AcOEt:cyclohexane, 1:1), the title compound was obtained (347 mg). Yield: 92%. 1H NMR (250 MHz, DMSO-d6) δ 7.13-7.17 (m, 2H, Harom 4+6), 7.25 (d, 1H, Harom 2, JF=10.0 Hz), 7.52 (q, 1H, Harom 5, J=8.1 Hz), 8.54 (s, 1H, HPz 5), 8.56 (s, 1H, HPz 3). m/z: 224.0 [(M)+, calcd for C10H6ClFN2O 224.0].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737152B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-0a219dd088c54b2fb90f64916136e86e |
| 출처 메모 | uspto-grants-2010_06 |