(1,1'-Biphenyl)-2-ol → 2-Chloro-6-(2-phenyl-phenyl-oxy)-pyrazine
반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[C:9]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[OH:21])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CCOC(C)=O.C1CCCCC1>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:21][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:3]=1참가 물질
5
실험 절차
Using Method DD (reaction time: 20 hours) with 2,6-dichloropyrazine (200 mg, 1.34 mmol) and 2-phenyl-phenol (268 mg, 1.49 mmol), and purification by column chromatography (AcOEt:cyclohexane, 1:2), the title compound was obtained (238 mg). Yield: 65%. 1H NMR (250 MHz, DMSO-d6) δ 7.31-7.61 (m, 9H, Harom), 8.43 (s, 1H, HPz 5), 8.46 (s, 1H, HPz 3). m/z: 283.1 [(M+H)+, calcd for C16H11ClN2O 282.1].
후처리
- customMethod DD (reaction time: 20 hours)
출처 및 근거
- ORD 기록
- ord-24ebe94632074f239808b788e9fadb14
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07737152B2
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