HCID 86664828, 화합물 → HCID 67497326, 화합물

반응식

Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:4][N:3]=1.[NH2:15][C:16]1NN=C(C2C=CN=C(NC)C=2)C=1>>[NH2:13][C:11]1[N:10]([CH3:14])[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:15][CH3:16])[CH:7]=2)[CH:12]=1

참가 물질

반응물 2

HCID 86664828HCID 86664828, 화합물

HCID 178482070HCID 178482070, 화합물

생성물 1

HCID 67497326HCID 67497326, 화합물수율 79%

실험 절차

This title intermediate was prepared starting from 23.A (2.10 g, 10.0 mmol) according the procedure described above for conversion of 18.0 to 18.D. The crude product was purified by flash chromatography using 0-10% MeOH/CH2Cl2 for elution to provide 23.B as white solid (1.61 g, 79%).

후처리

customThe crude product was purified by flash chromatography
washfor elution

출처 및 근거

ORD 기록: ord-71db85fd8d334e30b56879e7f0db2253
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08785468B2

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