Benzoic acid, 3-nitro-5-(4-pyridinyl)-, methyl ester → HCID 67497400, 화합물

HRID 1628282노트

반응식

HRID 1628282 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 1

HCID 46317472Benzoic acid, 3-nitro-5-(4-pyridinyl)-, methyl ester

생성물 1

HCID 67497400HCID 67497400, 화합물수율 95.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of methyl 3-nitro-5-(pyridin-4-yl)benzoate (45.1.B) (5.60 g, 21.62 mmol) in methanol (50 mL) was added 10% Pd on carbon by weight (2.50 g). The air was evacuated from the reaction flask and was replaced with hydrogen. The resulting slurry was stirred overnight at room temperature. The reaction mixture was then filtered and the mother liquor condensed to afford methyl 3-amino-5-(pyridin-4-yl)benzoate (45.1.C) (4.70 g, 95% yield) which was used in the next step without any further purification.

후처리

  1. customThe air was evacuated from the reaction flask
  2. filtrationThe reaction mixture was then filtered
  3. customthe mother liquor condensed

출처 및 근거

ORD 기록
ord-97098eac16c94e6abb8af39ea4354879
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785468B2

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