HCID 67497043, 화합물 → HCID 67496690, 화합물

HRID 1628294노트

반응식

HRID 1628294 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[C:10]([NH2:17])[CH:11]=[C:12]([N+:14]([O-])=O)[CH:13]=2)[CH:5]=[CH:4][N:3]=1>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([NH2:14])[CH:11]=[C:10]([NH2:17])[CH:9]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 1

HCID 67497043HCID 67497043, 화합물

생성물 1

HCID 67496690HCID 67496690, 화합물수율 91%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

To a rt solution of 51.1B (1.10 mg, 4.8 mol) in MeOH (10 mL) was added 5% Pd/C. The heterogeneous solution was stirred at 50° C. under H2 for 4.0 hr. To the resulting mixture was added celite, solid was filtered off and washed with MeOH. The combined liquid was concentrated under reduced pressure to provide the title product 51.1C as colorless solid (865 mg, 91%).

후처리

  1. additionTo the resulting mixture was added celite, solid
  2. filtrationwas filtered off
  3. washwashed with MeOH
  4. concentrationThe combined liquid was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f742faefde4f4870a607373327a9c3ad
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785468B2

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