Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Hydroxybiphenyl → 2-Chloro-6-(4-phenyl-phenyl-oxy)-pyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Hydroxybiphenyl | HCID 7103 | — |
| 반응물 | 2,6-Dichloropyrazine | HCID 78504 | — |
| 용매 | Cyclohexane | HCID 8078 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-Chloro-6-(4-phenyl-phenyl-oxy)-pyrazine | HCID 59343495 | 99% |
반응 단계
Using Method DD (reaction time: 20 hours) with 2,6-dichloropyrazine (200 mg, 1.34 mmol) and 4-phenyl-phenol (268 mg, 1.49 mmol), and purification by column chromatography (AcOEt:cyclohexane, 1:2), the title compound was obtained (376 mg). Yield: 99%. 1H NMR (250 MHz, DMSO-d6) δ 7.40-7.60 (m, 5H, Harom), 7.76 (d, 2H, Harom 3+5, J=7.1 Hz), 7.82 (d, 2H, Harom 2+6, J=8.7 Hz), 8.59 (s, 1H, HPz 5), 8.65 (s, 1H, HPz 3). m/z: 283.1 [(M+H)+, calcd for C16H11ClN2O 282.1].−
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737152B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-853c027b980d4cdf9f350bbb2b0b6699 |
| 출처 메모 | uspto-grants-2010_06 |