Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Hydroxyacetanilide → 2-Chloro-6-(3-acetamidophenyl-oxy)-pyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Hydroxyacetanilide | HCID 12124 | — |
| 반응물 | 2,6-Dichloropyrazine | HCID 78504 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-Chloro-6-(3-acetamidophenyl-oxy)-pyrazine | HCID 11543501 | 99% |
반응 단계
Using Method DD with 2,6-dichloropyrazine (200 mg, 1.34 mmol) and 3-acetamidophenol (202 mg, 1.49 mmol), and crystallisation in AcOEt, the title compound was obtained (350 mg). Yield: 99%. 1H NMR (250 MHz, DMSO-d6) δ 2.06 (s, 3H, CH3—NH), 6.90-6.95 (m, 1H, Harom 5), 7.76 (dd, 2H, Harom 4+6, Jm=2.0 Hz, Jo=7.6 Hz), 7.59 (s, 1H, Harom 2), 8.52 (s, 1H, HPz 5), 8.54 (s, 1H, HPz 3), 10.12 (s, 1H, NH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737152B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-e6a0f051b628495cba8a3695804c12d5 |
| 출처 메모 | uspto-grants-2010_06 |