Methyl 4-[(2,6-dinitrophenyl)amino]-3-hydroxybutanoate → Methyl 4-[(2,6-diaminophenyl)amino]-3-hydroxybutanoate

HRID 1628448노트

반응식

HRID 1628448 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[C:5]=1[NH:13][CH2:14][CH:15]([OH:21])[CH2:16][C:17]([O:19][CH3:20])=[O:18])([O-])=O>[Pd].O1CCCC1>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH2:10])[C:5]=1[NH:13][CH2:14][CH:15]([OH:21])[CH2:16][C:17]([O:19][CH3:20])=[O:18]

참가 물질

4

반응물 1

HCID 86632868Methyl 4-[(2,6-dinitrophenyl)amino]-3-hydroxybutanoate

생성물 1

HCID 68737495Methyl 4-[(2,6-diaminophenyl)amino]-3-hydroxybutanoate수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

Under hydrogen gas atmosphere, a mixture of methyl 4-[(2,6-dinitrophenyl)amino]-3-hydroxybutanoate (Reference Example 79; 2.53 g, 8.45 mmol), 10% palladium on carbon (50% wet, 500 mg) and tetrahydrofuran (85 mL) was stirred at room temperature for 6 hr. The reaction mixture was filtered and concentrated in vacuo to give the title compound as a solid (2.00 g, 8.36 mmol, 99%).

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-fc8257e62e5f472cad901fece4160824
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785460B2

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