Tetrahydrofuran → HCID 86632878, 화합물
반응식
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].Cl[C:7]1[C:12]([N+:13]([O-:15])=[O:14])=[CH:11][CH:10]=[CH:9][C:8]=1[N+:16]([O-:18])=[O:17].C(N(CC)CC)C.O1CCCC1>C(OCC)(=O)C>[N+:13]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:16]([O-:18])=[O:17])[C:7]=1[NH:1][CH2:2][CH2:3][CH2:4][OH:5])([O-:15])=[O:14]참가 물질
6
실험 절차
A mixture of 3-amino-1-propanol (6.77 mL, 89.0 mmol), 2-chloro-1,3-dinitrobenzene (15.0 g, 74.1 mmol), triethylamine (12.4 mL, 89.0 mmol) and tetrahydrofuran (370 mL) was stirred at room temperature for 12 hr. The reaction mixture was diluted with ethyl acetate, washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give the title compound as a solid (17.7 g, 73.3 mmol, 99%).
후처리
- washwashed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-176e97540bf9498bb05132951409f6e9
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08785460B2
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