Methanol → 4,6-Dimethoxy-2-methylpyrimidin-5-amine

반응식

[CH3:1][O-:2].[Na+].Cl[C:5]1[C:10]([NH2:11])=[C:9](Cl)[N:8]=[C:7]([CH3:13])[N:6]=1.[CH3:14][OH:15]>>[CH3:1][O:2][C:5]1[C:10]([NH2:11])=[C:9]([O:15][CH3:14])[N:8]=[C:7]([CH3:13])[N:6]=1

참가 물질

반응물 3

HCID 887Methanol

HCID 7366744,6-Dichloro-2-methylpyrimidin-5-amine

HCID 10942334Sodium Methoxide

생성물 1

HCID 212392004,6-Dimethoxy-2-methylpyrimidin-5-amine수율 100%

반응 조건

온도: 70 °C

실험 절차

Sodium methoxide (28% solution in methanol, 150 mL) was added dropwise to a stirred solution of 4,6-dichloro-2-methylpyrimidin-5-amine (15.0 g, 84.3 mmol) in methanol (150 mL) at 0° C., and the mixture was stirred at room temperature for 1 hr, at 70° C. for 6 hr. The mixture was concentrated, diluted with aqueous saturated ammonium chloride and extracted with ethyl acetate. The combined organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to give the title compound as a yellow solid (14.2 g, 84.3 mmol, 100%).