2,6-Dichloropyrazine → 2-Chloro-6-(indanone-5-oxy)-pyrazine

참여 물질

역할	이름	HCID	투입량
반응물	2,6-Dichloropyrazine	HCID 78504	—
반응물	5-Hydroxy-1-indanone	HCID 233147	—
용매	Ethyl Acetate	HCID 8857	—
생성물	2-Chloro-6-(indanone-5-oxy)-pyrazine	HCID 59343457	100%

반응 단계

Using Method DD with 2,6-dichloropyrazine (200 mg, 1.34 mmol) and 5-hydroxyindanone (219 mg, 1.49 mmol), and crystallisation in AcOEt, the title compound was obtained (350 mg). Yield: 100%. 1H NMR (250 MHz, DMSO-d6) δ 2.67 (t, 2H, H3, J=5.9 Hz), 3.13 (t, 2H, H2, J=5.5 Hz), 7.31 (dd, 1H, Harom 6, Jm=1.9 Hz, Jo=8.3 Hz), 7.47 (d, 1H, Harom 4, J=1.3 Hz), 7.73 (d, 1H, Harom 7, J=8.3 Hz), 8.59 (s, 1H, HPz 5), 8.64 (s, 1H, HPz 3). m/z: 261.0 [(M+H)+, calcd for C13H9ClN2O2 260.0].

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07737152B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-e265725f75314f558d749618500cb5f6
출처 메모	uspto-grants-2010_06