2,6-Dichloropyrazine → 2-Chloro-6-(quinoline-4-oxy)-pyrazine
반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[OH:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=[CH:12][CH:11]=1>CCOC(C)=O.C1CCCCC1>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[CH:12][CH:11]=2)[N:3]=1참가 물질
4
실험 절차
Using Method DD with 2,6-dichloropyrazine (250 mg, 1.69 mmol) and 4-hydroxyquinoline (270 mg, 1.49 mmol), and purification by column chromatography (AcOEt cyclohexane, 1:1), the title compound was obtained (60 mg). Yield: 14%. 1H NMR (250 MHz, DMSO-d6) δ 7.45 (d, 1H, Harom 3, J=4.9 Hz), 7.67 (t, 1H, Harom 7, J=7.6 Hz), 7.86 (t, 1H, Harom 6, J=7.8 Hz), 8.12 (d, 2H, Harom 3+5, J=8.7 Hz), 8.67 (s, 1H, HPz 5), 8.82 (s, 1H, HPz 3), 8.94 (d, 1H, Harom 2, J=4.9 Hz). m/z: 258.0 [(M+H)+, calcd for C13H8ClN3O 257.0].