Benzenamine, 3-bromo-4-methyl- → (3-Bromo-4-methyl-phenyl)-[1-(4-chloro-3-methyl-phenyl)-propyl]-amine

HRID 1629704노트

반응식

HRID 1629704 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][CH3:10])=[CH:4][C:3]=1[CH3:12].[Br:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][C:20]=1[CH3:21])[NH2:17].[B][B][B][B][B][B][B][B][B][B]>CO>[Br:13][C:14]1[CH:15]=[C:16]([NH:17][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([CH3:12])[CH:4]=2)[CH2:9][CH3:10])[CH:18]=[CH:19][C:20]=1[CH3:21]

참가 물질

5

반응물 3

HCID 82187Benzenamine, 3-bromo-4-methyl-HCID 391041011-(4-Chloro-3-methylphenyl)propan-1-oneHCID 178419135HCID 178419135, 화합물2회

생성물 1

HCID 67343963(3-Bromo-4-methyl-phenyl)-[1-(4-chloro-3-methyl-phenyl)-propyl]-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of INT 5 (3.00 g, 16.4 mmol) and 3-bromo-4-methylaniline (3.06 g, 16.4 mmol) in MeOH (164 mL) was added decaborane (1.00 g, 8.2 mmol). The reaction mixture was stirred at room temperature overnight. More decaborane (0.50 g, 4.1 mmol) was added. The mixture was stirred at 60° C. for 2 hours. The mixture was concentrated. The residue was purified by chromatography on silica gel (heptane/EtOAc) to afford INT 8.

후처리

  1. stirringThe mixture was stirred at 60° C. for 2 hours
  2. concentrationThe mixture was concentrated
  3. customThe residue was purified by chromatography on silica gel (heptane/EtOAc)
  4. customto afford INT 8

출처 및 근거

ORD 기록
ord-ed2fbaee727e43b5aeaa740330c55434
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791100B2

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