L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- → HCID 67010093, 화합물

HRID 1630056

반응식

HRID 1630056 반응식
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([O:7][C:8]2[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[CH2:17]([O:24][CH2:25][C@H:26]([NH:30]C(OC(C)(C)C)=O)[C:27](O)=[O:28])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[NH2:30][C@@H:26]([CH2:25][O:24][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:27]([NH:12][C:11]1[CH:13]=[CH:14][C:8]([O:7][C:6]2[CH:15]=[CH:16][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[CH:9][CH:10]=1)=[O:28]

참가 물질

3

반응물 2

HCID 90234L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-HCID 1014024-(4-Methoxyphenoxy)aniline

생성물 1

HCID 67010093HCID 67010093, 화합물수율 90%

실험 절차

Proceeding as in Reference 5, but substituting 4-(4-methoxyphenoxy)aniline and (S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoic acid, gave (S)-2-amino-3-(benzyloxy)-N-(4-(4-methoxyphenoxy)phenyl)propanamide (710 mg, 90%).

출처 및 근거

ORD 기록
ord-ef2937cacc4546b18551d4b0130012ab
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791102B2

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