2,5-dichloro-N-methylpyrimidin-4-amine → 4-(5-Chloro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxy-N-methylbenzamide
반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].Cl[C:15]1[N:20]=[C:19]([NH:21][CH3:22])[C:18]([Cl:23])=[CH:17][N:16]=1>>[Cl:23][C:18]1[C:19]([NH:21][CH3:22])=[N:20][C:15]([NH:1][C:2]2[CH:11]=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[CH:4][C:3]=2[O:12][CH3:13])=[N:16][CH:17]=1참가 물질
3
실험 절차
4-(5-Chloro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxy-N-methylbenzamide was prepared by the procedure described in Example 7 using 4-amino-3-methoxy-N-methylbenzamide and 2,5-dichloro-N-methylpyrimidin-4-amine. 1H NMR δ (ppm) (CDCl3): 8.58 (1H, d, J=8.4), 7.95-7.92 (1H, m), 7.70 (1H, s), 7.45 (1H, d, J=1.9), 6.09 (1H, s), 5.30 (1H, s), 4.03-3.95 (3H, m), 3.15-3.09 (3H, m), 3.02 (3H, t, J=4.8).
출처 및 근거
- ORD 기록
- ord-4358c8e49d2e4efdbf5731a80e9c0302
- 출처 데이터셋
- uspto-grants-2014_07