참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Naphthalenesulfonic acid | HCID 8420 | — |
| 반응물 | 4,5-Dihydro-2-(methylthio)thiazole | HCID 88324 | — |
| 반응물 | 4-Chloro-2,3-dihydro-1H-isoindole | HCID 14795868 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 19691974 | HCID 19691974 | — |
반응 단계
A mixture of 4-chloroisoindoline (700 mg), 2-methylthio-2-thiazoline (600 mg), and β-naphthylsulfonic acid (35 mg) was heated at 150° C. for 30 minutes. The product was cooled, dissolved in methylene chloride, washed with water, the organic layer dried over anhydrous potassium carbonate, filtered, and solvent removed from the filtrate under reduced pressure. The residue was chromatographed on silica gel packed in methylene chloride/2% methanol/ammonia, eluting with methylene chloride/2% methanol, to give 4-chloro-2-(thiazolin-2-yl)isoindoline, a compound of Formula (IA), m.p. 167°-169° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05726197 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-0591013fd92545f5bf5092992c26919f |
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| 출처 메모 | uspto-grants-1998_03 |
|---|
