5,6,7,8-Tetrahydro-1-naphthol → 6-(5,6,7,8-tetrahydronaphthalen-1-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine

HRID 16311

반응식

HRID 16311 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:13][C:14]2[CH:19]=[N:18][CH:17]=[C:16](Cl)[N:15]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[C:21]1([OH:31])[C:30]2[CH2:29][CH2:28][CH2:27][CH2:26][C:25]=2[CH:24]=[CH:23][CH:22]=1>>[C:21]1([O:31][C:16]2[N:15]=[C:14]([NH:13][C:5]3[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=3)[CH:19]=[N:18][CH:17]=2)[C:30]2[CH2:29][CH2:28][CH2:27][CH2:26][C:25]=2[CH:24]=[CH:23][CH:22]=1

참가 물질

3

반응물 2

HCID 682585,6,7,8-Tetrahydro-1-naphtholHCID 116090492-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine

생성물 1

HCID 248792076-(5,6,7,8-tetrahydronaphthalen-1-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine수율 13%

실험 절차

Using Method X with 150 mg of 2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine and 5,6,7,8-tetrahydro-1-naphthol, the title compound was obtained (27 mg). Yield: 13%. 1H NMR (250 MHz, DMSO-d6) δ 1.65-1.69 (m, 4H), 2.53-2.56 (m, 2H), 2.72-2.77 (m, 2H), 3.42 (s, 6H), 3.54 (s, 3H), 6.74 (s, 2H), 6.89 (d, 1H, J=7.9 Hz), 6.95 (d, 1H, J=6.6 Hz), 7.11 (t, 1H, J=7.8 Hz), 7.71 (s, 1H), 7.91 (s, 1H), 9.55 (bs, 1H). 13C NMR (62.9 MHz, DMSO-d6) δ 22.01, 22.26, 23.12, 28.78, 55.36, 60.03, 95.72, 118.40, 120.56, 125.66, 126.09, 127.60, 129.06, 132.10, 136.39, 138.76, 150.59, 151.46, 152.70, 157.65. m/z 408.2 [(M+H)+ calcd for C23H25N3O4 407.2].

출처 및 근거

ORD 기록
ord-6731532c0bca4a669530581d77111ac9
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737152B2

연결된 노트

불러오는 중…