Thionyl Chloride → HCID 66836706, 화합물

HRID 1631142노트

반응식

HRID 1631142 반응식
S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:11]=[C:10]([F:12])[C:9]([F:13])=[CH:8][C:7]=1[CH2:14]O>ClCCl>[Br:5][C:6]1[CH:11]=[C:10]([F:12])[C:9]([F:13])=[CH:8][C:7]=1[CH2:14][Cl:3]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 57518297(2-Bromo-4,5-difluorophenyl)methanol

생성물 1

HCID 66836706HCID 66836706, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
25 °C

실험 절차

146 μl of thionyl chloride in 2.5 ml of dichloromethane are added dropwise to 300 mg of (2-bromo-4,5-difluorophenyl)methanol in 2.5 ml of dichloromethane, and the mixture is stirred at 25° C. for 2 h. The mixture is evaporated to dryness in vacuo, the residue is taken up in 10 ml of toluene, and the operation is repeated. The residue is employed in the subsequent reactions without further treatment.

후처리

  1. customThe mixture is evaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-519333e6eb1048c18375e7995c396d7b
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791129B2

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