4-Aminotetrahydropyran → HCID 67501419, 화합물

HRID 1631351노트

반응식

HRID 1631351 반응식
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([OH:24])=O)=[C:15]3[N:14]=2)[CH:5]=[N:6][CH:7]=1.[O:25]1[CH2:30][CH2:29][CH:28]([NH2:31])[CH2:27][CH2:26]1>>[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([NH:31][CH:28]4[CH2:29][CH2:30][O:25][CH2:26][CH2:27]4)=[O:24])=[C:15]3[N:14]=2)[CH:5]=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 4192234-AminotetrahydropyranHCID 66847898(R)-5-(2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

생성물 1

HCID 67501419HCID 67501419, 화합물수율 90%

실험 절차

Prepared by the method as described in Example 1 using (R)-5-(2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation I) and tetrahydro-2H-pyran-4-amine to yield the title compound as a white solid (34 mg, 90% yield). MS (apci) m/z=411.1 (M+H).

후처리

  1. customPrepared by the method

출처 및 근거

ORD 기록
ord-8e1330d4881d46f2a4758463230bd7c3
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791123B2

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